Integrating Genomics, RNA Therapeutics and Precision Medicine
for Rare and Complex Diseases.
Science is not merely the production of knowledge; it is a culture, an uncompromising discipline, and a shared responsibility.
We are a collaborative scientific ecosystem where clinicians, geneticists, molecular biologists, and physician-scientists work together to translate biological discoveries into clinical solutions.
Our research combines genomics, transcriptomics, immunology, cell biology, and precision medicine to understand disease mechanisms and develop next-generation diagnostic and therapeutic approaches.
To bridge molecular discoveries and clinical medicine through cutting-edge genomics, RNA biology, immunology, and precision medicine, enabling innovative diagnostic and therapeutic strategies for rare and complex diseases.
To become an internationally recognized translational research ecosystem that integrates multidisciplinary science, advanced genomic technologies, and clinical innovation for the benefit of patients worldwide.
Translational Medicine Lab (TML) is a multidisciplinary research laboratory at Hacettepe University Faculty of Medicine, bringing together clinicians and basic scientists to bridge genomic discoveries with clinical medicine.
We ask meaningful scientific questions that challenge existing knowledge and open new paths toward discovery.
We believe rigorous methodology, transparency, reproducibility, and scientific integrity are the foundations of impactful research.
Scientific breakthroughs emerge from multidisciplinary teamwork, open communication, mutual respect, and shared responsibility.
Our laboratory is organized around six research programs spanning rare disease genomics, immunology, RNA therapeutics, and precision medicine.
Decoding the genetic basis of rare diseases through long-read sequencing, whole-genome analysis, transcriptomics, and functional interpretation of genomic variation.
Investigating the molecular mechanisms of hereditary autoinflammatory disorders through integrated genomics, immunology, transcriptomics, and precision medicine approaches.
Advancing the diagnosis and treatment of inherited retinal disorders using genomics, transcriptomics, disease modeling, and innovative therapeutic strategies.
Exploring the genomic architecture of hereditary and sporadic cancers to improve molecular diagnosis, risk assessment, and personalized therapeutic approaches.
Developing RNA-based therapeutic strategies including antisense oligonucleotides (ASOs), splice modulation, allele-specific therapies, and RNA precision medicine.
Translating genomic discoveries into individualized diagnostics and targeted therapeutic solutions through multidisciplinary translational research.
A multidisciplinary team of clinician-scientists bridging genetics, rheumatology, and computational medicine.
State-of-the-art equipment enabling cutting-edge research across genomics, molecular biology, and clinical translation.
"Technology does not build a laboratory. People do."
The most valuable resource of our laboratory is not our instruments, but the researchers who share a common vision, scientific integrity, and collaborative culture. We believe that sustainable scientific excellence is built through curiosity, discipline, and teamwork.
Selected publications from our team. Filter by year or research area.
Recent publications, grants, conference presentations, and laboratory updates.
We welcome collaborations, visiting researchers, and prospective students.